There was also a clear dose-response relationship for sedation, mental clouding, and other central nervous system (CNS) related side effects. Because of sedation, the 20-mg dose was judged to be “of limited value for most patients.” The second study in 36 cancer patients compared placebo, 10, and 20 mg of 9-THC and 60 and 120 mg of codeine over a 7-hour observation period (Noyes et al. 1975b) cannabis seeds. Codeine 120 mg and 9-THC 20 mg were similar to each other and significantly superior to placebo for the sum of the pain intensity differences and total pain relief, while other pairwise contrasts were not significant. Relative potency analysis was not performed.